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March 2, 2024NeuropharmacologyOpen Access

Quantitative T2 mapping-based longitudinal assessment of brain injury and therapeutic rescue in the rat following acute organophosphate intoxication

Alita Jesal D Almeida Brad A. Hobson Naomi Saito Donald A. Bruun Valerie A. Porter Danielle Harvey Joel R. Garbow Abhijit J. Chaudhari Pamela J. Lein

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Key Points

Quantitative T2 mapping provides noninvasive assessment of acute brain injury and tracks therapeutic rescue, resolving limitations of existing countermeasures.
Assessment in a rat model of diisopropylfluorophosphate intoxication evaluates longitudinal neural damage, tracking responses without reported survival metrics.
Supports developing sensitive neuroimaging endpoints for organophosphate intoxication therapies; preclinical rat model requires further translational validation.

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Implication

Experimental study demonstrates quantitative T2 mapping for brain injury and therapeutic rescue in rats, highlighting neuroimaging potential.

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Cite This Study

Almeida et al. (2024) studied this question.

synapsesocial.com/papers/68e7603ab6db6435876d6bb0 https://doi.org/10.1016/j.neuropharm.2024.109895

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A longitudinal MRI and TSPO PET-based investigation of brain region-specific neuroprotection by diazepam versus midazolam following organophosphate-induced seizures2024 · 5 citations
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3Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult ratsOriginal Research · 2025 · 1 citations
4Acute intoxication with diisopropylfluorophosphate promotes cellular senescence in the adult male rat brain2024 · 1 citations
5Quantification of 11 metabolites in rat urine after exposure to organophosphates2024 · 1 citations