March 1, 2024mBioOpen Access

Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1

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Authors

XBXavier BonnerUniversity of North Carolina at Chapel Hill ASAmy SondgerothUniversity of North Carolina at Chapel Hill AMAmelia C. McCueUniversity of North Carolina at Chapel Hill

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Implication

Biochemical and modeling analysis reveals single-receptor CD4 entry mechanisms in macrophage-tropic HIV-1 variants, highlighting structural drivers of viral tropism evolution.

Key Points

Macrophage-tropic HIV-1 requires only 1 CD4 receptor interaction to mediate cell entry, whereas T-tropic virus lineages require multiple CD4 molecules for infection.
Dose-response modeling of viral infectivity across varied CD4 surface densities reveals that T-tropic Env protein trimers bind and release target cells more slowly.
Enhanced gp120 subunit affinity supports macrophage tropism evolution during T-cell depletion, highlighting mechanisms underlying central nervous system viral entry.

Cite This Study

Bonner et al. (2024) studied this question.

synapsesocial.com/papers/68e76346b6db6435876d942f https://doi.org/10.1128/mbio.00321-24

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Implication

Biochemical and modeling analysis reveals single-receptor CD4 entry mechanisms in macrophage-tropic HIV-1 variants, highlighting structural drivers of viral tropism evolution.

Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1

Discussion

Member takes

Implication

Key Points

Cite This Study

Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1

Discussion

Member takes

Implication

Key Points

Cite This Study

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