• Programmed Cell Death Protein 1 (PD-1), in regulating immune responses against cancer. • PD-1 is a critical mechanistic player to prevent autoimmunity and maintain peripheral tolerance. • PD-L1, PD-L2 methylation and immune cell infiltration are strongly correlated. • PD-L1 and PD-L2 methylation may serve as predictive biomarkers HNSCC.
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Prasad et al. (2024) studied this question.
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