March 1, 2024Research in Pharmaceutical SciencesOpen Access

In vitro and in vivo assessment of indomethacin-induced genotoxicity: protection by curcumin

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EZEhsan ZamaniImam Hossein University RKReza Alipour Klour ASAmirreza Gholami Shekarsarayi

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Implication

Preclinical study demonstrates that curcumin reduces indomethacin-induced genotoxicity and oxidative stress in cell and mouse models, highlighting potential protective antioxidant mechanisms.

Key Points

Curcumin treatment significantly attenuates indomethacin-induced genotoxicity and reduces oxidative stress in both cultured human cells and murine bone marrow models.
Pretreatment with 100 mg/kg curcumin markedly increased cellular glutathione levels, while significantly suppressing micronuclei formation and malondialdehyde in mice.
Highlights the protective antioxidant capacity of curcumin against anti-inflammatory drug toxicity—mouse model; further preclinical validation is required.

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Zamani et al. (2024) studied this question.

synapsesocial.com/papers/68e764abb6db6435876da805 https://doi.org/10.4103/rps.rps_100_23

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Implication

Preclinical study demonstrates that curcumin reduces indomethacin-induced genotoxicity and oxidative stress in cell and mouse models, highlighting potential protective antioxidant mechanisms.

In vitro and in vivo assessment of indomethacin-induced genotoxicity: protection by curcumin

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Implication

Key Points

Cite This Study

In vitro and in vivo assessment of indomethacin-induced genotoxicity: protection by curcumin

Discussion

Member takes

Implication

Key Points

Cite This Study

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