Supplementary Figures 1-6 from IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation

Supplementary Figure 1. IDH2 is mutated in preleukemic hematopoietic stem cells in relapse causing clones in AML. Supplementary Figure 2. Single-cell RNA sequencing and combined genotyping reveal distinct transcriptomic profiles of IDH1-mutant pHSCs in AML Supplementary Figure 3. Modeling human pHSCs using CRISPR/Cas9 with HDR show reduced proliferation and blocked differentiation caused by IDH1 mutations Supplementary Figure 4. IDH1 mutations reduce 5-hydroxymethylcytosine in gene bodies Supplementary Figure 5. IDH1 mutations drives transcriptomic alterations Supplementary Figure 6. IDH1-mutant pHSCs are sensitive to inhibition of oxidative phosphorylation