COVID-19 Vaccination During Pregnancy Is Safe for Neonates

Research Article| March 01 2024 COVID-19 Vaccination During Pregnancy Is Safe for Neonates AAP Grand Rounds (2024) 51 (3): 27. https://doi.org/10.1542/gr.51-3-27 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation COVID-19 Vaccination During Pregnancy Is Safe for Neonates. AAP Grand Rounds March 2024; 51 (3): 27. https://doi.org/10.1542/gr.51-3-27 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: covid-19 vaccines, vaccines Source: Jorgensen SCJ, S M Drover SSM, Fell DB, et al. Newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy. JAMA Pediatr. 2023;177(12):1314-1323; doi: https://doi.org/10.1001/jamapediatrics.2023.4499.Google Scholar Investigators from multiple institutions in Canada conducted a retrospective cohort study to determine if maternal messenger RNA (mRNA) COVID-19 vaccination during pregnancy increased the risk of adverse outcomes in their infants. For the study, they identified live births in Ontario, Canada, with an expected delivery date between May 1, 2021, and September 2, 2022. Multiple health administrative databases were used to link maternal-newborn dyads and collect data on newborn outcomes. Information on maternal COVID-19 vaccination was obtained from a centralized vaccine registry in Ontario. Infants were considered exposed to COVID-19 vaccine if their mother received 1 or more doses between estimated day of conception and birth. Day of conception was calculated using estimated gestational age at birth. Study outcomes included severe neonatal morbidity (SNM), a validated measure of neonatal outcomes that includes 15 diagnoses and 7 procedures within the first 28 days of life, neonatal mortality (death during the first 28 days of life), NICU admissions, and hospital readmission within the first 28 days of life or in the first 6 months. Data on multiple sociodemographic and clinical characteristics were used to calculate propensity scores to allow adjusting for multiple covariates. After propensity score weighting, adjusted rate ratios (aRRs) were calculated to compare risks of SNM, NICU admission, or neonatal death among the cohort of COVID-19 vaccine-exposed infants to those in the unexposed cohort. Cox proportional hazard regression was used to estimate hazard ratios (HRs) for hospital readmissions. Data were collected on 142,006 infants. There were 85,670 infants exposed to COVID-19 vaccine in utero, with 48.6% exposed to 1 dose, 49.6% exposed to 2 doses, and 1.8% exposed to 3 doses. Mothers who were vaccinated during pregnancy were more likely to be >30 years old, residents of urban areas, and have higher incomes than those who didn’t receive a COVID-19 vaccine. After adjusting for these and other differences using propensity score weighting, the risk of SNM was significantly lower in the cohort of vaccine-exposed infants than in those who were unexposed (aRR, 0.86; 95% confidence interval [CI], 0.83, 0.90), with SNM occurring in 7.3% and 8.3%, respectively. Similarly, neonatal death occurred in 0.09% and 0.16%, respectively, of infants in the vaccine-exposed and unexposed cohorts (aRR, 0.47; 95% CI, 0.33, 0.65), and 11.4% and 13.1%, respectively, had a NICU admission (aRR, 0.86; 95% CI, 0.83, 0.89). There were no significant differences between cohorts for risk of hospital readmission during the first 28 days (HR, 1.03; 95% CI, 0.89, 1.09) or during the first 6 months of life (HR, 1.01; 95% CI, 0.96, 1.05). The authors conclude that prenatal exposure to maternal COVID-19 vaccine was associated with a lower risk of SNM, neonatal death, and NICU admission. Dr Beam has disclosed no financial relationship relevant to this... You do not currently have access to this content.