TBAI‐Catalyzed, TBHP‐Mediated Modular Three‐Component Cascade Towards Highly Functionalized Pyrrole via [3+2] Annulation

A facile, one‐pot sequential synthesis of highly substituted pyrrole employing TBAI/TBHP has been developed from readily available precursors. β ‐Enaminones generated in situ from β ‐ketoesters and primary amines react sequentially with electron‐deficient alkynes via a radical pathway to form the penta‐substituted pyrroles in moderate to good yields. This strategy for the synthesis of highly functionalized pyrroles can be scaled up and shows tolerance to a variety of amines.