1209 Uterine sarcomas: clinical and histopathological aspects. About 5 cases

Introduction/Background Uterine sarcomas are rare tumors of the uterus with a poor prognosis. They are characterized by great histological heterogeneity and their symptomatology is nonspecific. The aim of this study is to review our experience with uterine sarcomas, to analyze their histopathological and clinical features Methodology This is a retrospective study of cases of uterine sarcomas treated in our departmen, between 2018 and 2023. We were interested in patients' clinical characteristics, anatomopathological features, types of treatment and patient outcome. Results From 2018 to 2023, 5 cases of sarcoma were managed in our department. Our study included 3 histological types: leiomyosarcoma (n = 3), rhabdomyosarcoma (n = 1) and carcinosarcoma (n = 1),The average age of patients at diagnosis was 55.4 years . Metrorrhagia was the most frequent initial symptomatology in 4 patients .in 4 patients, the diagnosis of sarcoma was made retrospectively after histological analysis of the hysterectomy specimen, and in only 2 of these patients had the combination of clinical examination and pelvic ultrasound led to the suspicion of malignant pathology.All patients underwent surgical treatment: total hysterectomy with bilateral adnexectomy in all, and additional pelvic lymphadenectomy in only one. complementary treatment was combined with surgery: radiocuretherapy in one case, brachytherapy in one case and chemotherapy in one case. At the time of analysis, 1 patient was lost to follow-up, 1 patient died, and with an average follow-up of 13 months, the evolution was favorable in 3 patients. Conclusion Uterine sarcomas are rare cancers with a poor prognosis. These tumors have no specific symptomatology and are characterized by great anatomopathological heterogeneity. Their diagnosis must be made early, as patient survival is correlated with the tumor stage at discovery. Paradoxically, diagnosis is often delayed and made retrospectively on histological analysis of the hysterectomy specimen. Disclosures Les auteurs ne déclarent pas un conflit d'intérêt.