731 Correlation of axillary ultrasound results with histological data in the early detection of nodal involvement in breast cancer

Introduction/Background Breast cancer is currently the most common malignancy in women worldwide, including Tunisia. Early diagnosis is crucial for improving the prognosis of breast cancer. The combination of mammography and axillary ultrasound has become an integral part of preoperative evaluation. With technological advancements, the axillary lymph node status has emerged as a major prognostic factor. Numerous studies have evaluated the utility of axillary ultrasound (AUS) in the preoperative nodal staging of breast cancer. Methodology In a prospective study conducted over 6 months, we included 60 patients managed at the Department of Obstetrics and Gynecology of CHU Farhat Hached Sousse, who had early-stage breast cancer (T1-T2, N0) and no clinical evidence of axillary involvement. These patients underwent preoperative axillary ultrasound performed by the same operator to identify ultrasound signs of nodal invasion. Results The study population had a mean age of 53.2 years, with 13.3% having a family history of breast neoplasia. In most cases, the cancer was detected through screening mammography, with an average duration of approximately 4 months. Tumors measuring between 2 and 5 cm were the most frequently observed (68.3% of cases). All patients underwent a combined examination of breast ultrasound and axillary ultrasound. In our study, ACR 4 and ACR 5 lesions accounted for 56.7% and 41.7% of cases, respectively. Additional axillary ultrasound was performed to identify characteristics suggestive of suspicious lymph nodes. Pathological analysis of the radiological findings showed a histological concordance ranging from 70% to 84.6%. Conclusion Axillary nodal metastasis is a major prognostic factor in breast cancer. Axillary ultrasound (AUS) is currently the most relevant complementary examination for axillary exploration and serves as the gold standard for routine preoperative assessment. In the context of surgical de-escalation, the diagnostic performance of axillary ultrasound in detecting nodal involvement needs to be redefined. Disclosures All authors declare that they have no conflicts of interest.