49 Is minimally invasive surgical approach a reasonable option in apparent early stage epithelial ovarian cancer restaging? Results from a multicentric retrospective study

Introduction/Background To perform surgical staging of early stage ovarian cancer (EOC), conventionnal laparoscopy (LS) and robot-assisted laparoscopy (RLS) appear to be reliable procedures compared to open surgery. But oncologicals results with long-term follow up are limited in the literature. The objective of this study is to evaluate the surgical and long-term survival for patients managed by minimally invasive surgery (MIS). Methodology We conducted a multicentric retrospective study in 6 institutions. All patients refered for epithelial EOC (apparent stage I-IIa) managed with LS and RLS were involved. Results From December 2008 to December 2017, 140 patients were included (109 in LS group and 31 in RLS group). A total of 27 (19.2%) patients were upstaged to an advanced ovarian cancer, and 73% of patients received chemotherapy. Mean operative time was 265,8 ± 88,4 min and significantly longer in RLS group (LS = 254,5 ± 86,8 ; RLS = 305,6 ± 85,5 ; p = 0,008). Post-operative complications were mainly grade 1 and 2 (LS : 20,2% and RLS : 29%). Thirteen conversion to laparotomy occurred, including one per-operative hemorrhaege. After a mean follow-up of 60,7 months, 29 (20.7%) patients recurred, with a time to recurrence was > 24 months in 51,7% of cases. Overall survival (OS) was 79,3% and disease-free survival (DFS) was 88,6%. Oncologic outcomes were similar between LS and RLS group. Conclusion Surgical staging of EOC by LS or RLS approach has long-term equivalent surgical and oncological approach. These results seem to be equivalent to open surgery according to literature review. Disclosures No discosures to report.