260 ViRP signature predicts response to treatment with chemotherapy and bevacizumab in ovarian cancer – a translational study of the ICON-7 trial’

Introduction/Background Antiangiogenic therapy using bevacizumab has proven effective for patients with advanced ovarian cancer. However, there is still an unmet need in ovarian cancer to identify patients who benefit from such treatment. The nine-protein signature score vascular endothelial growth factor inhibition response predictor (ViRP) has been shown predictive for response in patients with HER2-negative breast cancer. Methodology ICON7 was an international, phase 3, open-label, randomized trial assigning patients with either high-risk early-stage disease or more advanced disease to standard chemotherapy +/- bevacizumab, given concurrently and continued in maintenance therapy. DASL gene expression arrays have been performed on FFPE tissue from patients enrolled in the German contribution to the trial. The mRNA based ViRP score was calculated using quantile normalized and probe averaged mRNA expression values and its association with clinical outcome was studied. Results mRNA expression was available for 359 patients, of whom 189 patients were treated with bevacizumab. We used the earlier determined cut-off Conclusion The ViRP score is predictive for survival benefit of treatment with chemotherapy with bevacizumab in patients with ovarian cancer. This indicates a tumor agnostic signal which identifies patients deriving the largest benefit from adding bevacizumab. Disclosures KL: Receipt of grants/research supports: GSK, research funding paid to Institution; Receipt of honoraria or consultation fees: Advisory board fees: Astra Zeneca, Nycode, GSK, Eisai FH: Receipt of honoraria or consultation fees: Novocure, PharmaMar, Astra Zeneca, Roche, Tesaro, GSK, Clovis, Amedes, NewOncology, Zailab RK: Receipt of honoraria or consultation fees: Astra Zeneca, MSD; GSK, Roche, Novocure JS: Research Funding: Institution: AZ, Clovis Oncology, Merck, Bayer, PharmaMar, Pfizer, Tesaro, MSD Oncology, Roche. Consulting/Ad Bds: AZ, Clovis Oncology, PharmaMar, Merck, Pfizer, Tesaro, MSD Oncology, Lilly, Novocure, J Honoraria: AZ, Eisai, Clovis Oncology, Olympus Medical Systems, J Travel, Accommodations, Expenses: AZ, Clovis Oncology, PharmaMar, Roche Pharma AG, Tesaro, MSD Oncology, Olympus.