493 Endometrial cancer: discrepancy between FIGO stage and radiosurgery, discrepancy between histological type and grade before and after surgery.about 62 cases

Introduction/Background Endometrial cancer is one of the most common gynaecological tumours in the world. Its incidence is increasing, especially in industrialised countries. It is treated mainly by surgery, but unfortunately it is sometimes treated either excessively or inadequately, given the discrepancies between pre- and post-op (FIGO stage, histological type and grade). It should be noted that the new classification into 4 prognostic risk groups incorporates molecular analysis data (p53, MSI, POLE) to guide the initial surgical management as well as the modalities of adjuvant treatment. Methodology Retrospective study carried out in the Gynaecology and Obstetrics II Department of the Hassan II University Hospital, Fez, between January 2019 and August 2022 on 62 cases of endometrial cancer. The data were collected from the patients9 files and the Multidisciplinary Consultation Meeting forms. Results The FIGO classification was concordant in 49% of cases, both pre- and postoperatively. The most frequent histological type was endometrioid adenocarcinoma in 67%, with a discordance in 31% especially in the other types, concerning the histological grade we had a percentage of 14,28% of Upgrade contrary to 19% of Down grade in a group where the histological type is obtained by pipelle of cornier .et we had an upgrade of 10% and Downgrade of 20% in the group where the histological type made by a directed biopsy. Conclusion Our study showed a clear discrepancy between the pre- and post-operative results, hence the interest of the new classification into 4 prognostic risk groups incorporating molecular analysis data (p53, MLH1, PMS2, MSH6, MSH2, POLE) to guide the initial surgical management as well as the modalities of adjuvant treatment. Disclosures The authors have no conflicts of interest to declare.