301 Relapse of vulvar squamous cancer: prevalence and associated risk factors

Introduction/Background Vulvar cancers(VC) are uncommon and affect predominantly elderly women. Incidence is increasing over the last decades, especially in women <60 years. High recurrence and morbimortality rates are described. The most well-known risks factors of recurrence are: lymph node involvement(N+), tumour size and presence of vulvar intraepithelial neoplasia(VIN). Study objectives - Main objective: to describe recurrence rate(RR) of VC in our centre. - Secondary objectives: to know the five years overall survival(OS), disease specific survival(DSS), Event-free survival(EFS) of VC-patients treated in our centre. To compare OS, DSS, EFS and RR when N+ and in cases with margins of resection are affected by VIN. Methodology Unicentric retrospective observational study Patients treated for VC with a curative intention under follow-up in our centre between 2005 and 2020. Statistical analysis performed with SPSS(v28). Excluding criteria: non-squamous cell carcinoma, loss of follow-up, debulking or palliative surgeries. Results 46 patients were included. The mean age was 73 years(33–91). 17 patients presented a recurrence(RR 37%). Five-year OS and DSS were 30% and 50% respectively. 80% of patients treated on 2020 were free of disease. Patients with N+ presented a higher RR (X² p<0.05). OS(long rank p=0,088), DSS(long rank p<0.05) and EFS(long rank p<0.05) were poorer in patients with N+. Patients with VIN on margins presented poorest results buy they did not have achieved statistical signification(RR, OS, DSS, EFS p>0.05). Conclusion Our study population had a RR similar to literature data. However we detected a poorer OS and DSS than literature data. These might be explained by an elderly study population with high comorbidities. Patients with N+ had worse results with higher RR both local or on inguinal nodes. Patients with VIN affecting margins presented higher RR but without statistical significance, perhaps due to a small sample, which might be the main limitation of our study. Disclosures No.