effect of wisp-1 on collagen turnover in primary airway smooth muscle cells: implications for asthma and copd airway remodeling

Introduction Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory conditions characterized by distinct airway remodeling patterns, with collagenous proteins playing a crucial role in extracellular matrix alterations. This study delves into the impact of WNT-inducible signaling pathway protein-1 (WISP-1), a target gene of canonical Wnt signaling, on collagen synthesis and deposition in airway smooth muscle cells (ASMC) from patients with asthma and COPD.