A Case of LGI1 Encephalitis Presenting with NORSE

New-onset refractory status epilepticus (NORSE) is a rare, life-threatening clinical presentation in patients without a known history of epileptic seizures.Autoimmune encephalitis is the most common cause identified in adults; however, in up to 50% of cases, no cause can be found.We present a case of a previously healthy 26-year-old male admitted to the intensive care medicine with NORSE, whose condition improved with the initiation of immunotherapy.Later, he was diagnosed with anti-leucine-rich glioma-inactivated 1 (anti-LGI1) antibody encephalitis.Despite prompt initiation of immunotherapy, cognitive function deterioration and resistant seizures persisted.NORSE is a critical condition that requires urgent treatment.In patients with a negative initial work-up, a preliminary diagnosis of autoimmune encephalitis should be considered.It is critical to begin immunotherapy before the autoimmune encephalitis panel results, as early treatment improves outcomes and long-term prognosis.