4CPS-044 Pre-exposure prophylaxis drop-out: follow-up and relinking through telephone contact

Background and Importance Pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy for people at high risk of infection. Long-term adherence to PrEP program in our health care setting is unknown. Aim and Objectives To identify users who dropped out PrEP and to evaluate the usefulness of telephone contact for recapturing, through a multidisciplinary strategy (Infectious Diseases-Pharmacy). Material and Methods Transversal study on a cohort of PrEP users (April 2022-July 2023). Potential users without drug dispensing in the last three-months were identified. Clinical histories were reviewed to determine 'true treatment discontinuations' (TTD). Those patients were contacted by telephone to offer relinking. Statistical analysis: values were expressed as medians (interquartile range-IQR) and patients (percentages). Results Follow-up in 292 users: 47 (16%) potential dropouts, 23 (7.9%) TTD. The remaining 24: 15 cases were suitable discontinuations, 1 unsuitable discontinuation, 3 used PrEP on demand without requiring standard dispensing, 1 was transferred to another hospital and 4 were awaiting dispensation. Conclusion and Relevance Adherence to PrEP program is a healthcare challenge. Users showed high risk of HIV and STI transmission, and PrEP drop-out could lead to new avoidable HIV infections. Telephone contact could be insufficient to guarantee continuity in this program. The collaboration of Infectious Diseases and Pharmacy Department ensures communication with these users and retention in this program. References and/or Acknowledgements Conflict of Interest No conflict of interest.