4CPS-039 Abstract withdrawn

Background and Importance Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity in the world. Aging decreases organ function which can also include renal impairment. Decreased renal function may increase the risk of adverse drug events and requires dose adjustment. More than half of the elderly patients are exposed to polytherapy (five or more drugs). Polytherapy complicates drug management and increases the risk of potentially inappropriate medications (PIMs) and drug-drug interactions (DDIs) which can complicate the course of treatment and threaten patient safety. Aim and Objectives The aim of the study was to evaluate the prevalence of drug-related problems using the 'Best possible medication history' (BPMH) and the prevalence of cardiovascular drugs among identified drug-related problems. Material and Methods The study included 105 patients aged 65 years or older, admitted to Dubrava University Hospital, Department of Cardiology. Polypharmacy was defined as the simultaneous use of 5–9 drugs, while the use of 10 drugs and more was defined as excessive polypharmacy. The EU (7)-PIM criteria were applied for PIMs detection. Potential DDIs were detected using Lexicomp software. The analysis of inappropriately prescribed renal risk drugs was performed in patients with eGFR < 60 ml/min/1.73 m² (KDIGO stages G3a, G3b, G4 and G5). Results The research determined the presence of polypharmacy in 56.2% of patients, while 27.6% of them used 10 or more medications. Drugs belonging to ATC group C accounted for 47.6% of all drugs in patients with polytherapy and 43.7% of all drugs in patients with excessive polypharmacy. PIMs were found in 74.3% of patients, of which 20.7% were ATC group C. At least one potential clinically significant interaction was found in 93.3% of patients, of which 72.1% involved drugs of ATC group C. A total of 35 renal risk drugs were detected in patients with renal impairment, of which 62.9% of drugs belonged to ATC group C. Conclusion and Relevance This research determined high exposure to pharmacotherapy problems in elderly patients with CVD. Cardiovascular drugs were significantly represented in the analysed pharmacotherapeutic problems. The obtained data highlights the importance of using the BPMH in determination of pharmacotherapy problems in elderly patients with CVD. References and/or Acknowledgements Conflict of Interest No conflict of interest.