Abstract 2010 LncRNA based novel mediators of inflammation and metabolism

Noncoding RNAs are emerging as crucial players in regulation of gene expression, cell signaling, and metabolism. Studies from our laboratory demonstrated that lncRNA HOTAIR regulates inflammatory response in macrophages and modulates cytokine expression via regulation of NF-kB activation. Additionally, we also discovered a series of novel lncRNA modulators of inflammation in mice and human, termed as Long-noncoding inflammation associated RNA, LinfRNA). Some of these hLinfRNAs (such as hLinfRNA1) control NF-kB signaling and some others regulate JAK/STAT signaling. Additionally, hLinfRNAs also regulate glucose metabolism and lipid homeostasis in macrophages during inflammatory response. Here, we will present our recent studies in functional characterization of selected inflammatory lncRNAs in regulation of cytokine expression, NF-kB signaling, and their roles in glucose/lipid metabolism during inflammation and macrophage activation. Overall, our studies demonstrated that lncRNAs are novel regulator of inflammation and metabolism and hence have potential towards discovery of novel biomarkers and therapeutic targets for inflammatory human disease. Chini A., Guha P., Malladi V. Zhang G. and Mandal S.S. *, Novel long-noncoding RNAs associated with inflammation and macrophage activation in Human, Scientific Reports 2023,13 (1), 4036. Obaid M., Udden S.M.N., Alluri P. and Mandal S.S.*, LncRNA HOTAIR regulates glucose transporter Glut1 expression and glucose uptake in macrophages during inflammation, Scientific Reports 2021, 11: 232. Research in Mandal laboratory is supported by grants from NIH (1R15 HL142032-01, R15HL170257), NSF grant – 2243017, and funding from The Schwartzberg Companies.