Abstract 2074 The Effects of Resveratrol on Neuroinflammation

Alzheimer's disease is a neuroinflammatory disorder causing dementia, cognitive impairment and neurodegeneration. According to the Alzheimer's Association, more than 6 million Americans are living with Alzheimer's disease. By 2050, this number is projected to rise to nearly 13 million, yet there is currently no effective treatment available to cure this disease. Neuroinflammation and immune signaling pathways involve various genomic and protein-based factors, such as cytokines, interferons, and long noncoding RNAs (lncRNAs). Our study is focused on understanding the regulatory mechanisms underlying the complexity of this prevalent disease and developing advanced therapeutic approaches. Resveratrol is a polyphenolic compound naturally occurring in many plants such as grapes, berries, and peanuts, known for its antioxidant, anti-inflammatory, and anticancer activity. The goal of this study is to perform an in vitro analysis of the effects of resveratrol on mouse and human microglia cells to determine its effectiveness at reducing neuroinflammation. In this study, we investigated the effect of resveratrol on known biomarkers and protein-based factors, along with lncRNAs which have been reported as crucial players in neuroinflammation. The analysis is performed by quantifying RNA and protein levels of inflammatory genes and cytokines. Analyzing the expression of lncRNAs under neuroinflammation reveals new aspects of gene regulation in neurodegenerative disorders. Our results indicate that resveratrol could potentially hold implications as a preventive and therapeutic candidate for Alzheimer's and other neuroinflammatory diseases. This research was made possible by NIH.