Comparison Between Albumin and Crystalloid as Priming Solution in Cardiopulmonary Bypass Paediatric Cyanotic Heart Disease Patients Admitted for Surgery.

Effects on platelet number and function are a central concern in choice of priming uid on congenital cardiac patients. Aim to compare between albumin and crystalloid with FFPas priming solution in cardiopulmonary bypass for paediatric congenital cyanotic heart disease patients (CHD). A total of 66 CHD paediatric patients were divided into two groups to received either albumin or crystalloid solution +FFP as priming uid. The primary endpoint was assessment of haemoglobin, platelet count and urine output immediately before induction and after cessation of CPB. Secondary endpoints considered blood loss and consumption of blood products in post operative 24 hrs period. Statistically signicant difference revealed between the two groups for post CBP Hb,(Gr.albumin10.55±1.32:Gr.cr+FFP 9.91± 1.07; p0.033) post CBP platelet (Gr. Albumin 115151.52±29487.41: Gr.Cr +FFP 139393±23040.64; p 0.000), post CBP urine(Gr.Albumin 869.94±282.67:Gr.Cr+FFP 1051.67±235.48;p 0.006), left drain collection,(Gr albumin 25.30±4.49: Gr Cr 43.03± 7.88;p0.05) right drain collection Gr Albumin 15.15±3.36:Gr Cr 38.33± 7.01; p 0.005), PRBC transfused (Gr Albumin 50.91±13.77:Gr Cr+FFP 114.27±19.05 ;p0.009), and platelet transfusion(Gr Albumin 75.8%:Gr Cr+FFP 24.2%; p 0.003) . Albumin in the prime may attenuate the extravasations of uid out of the vascular space, Moreover systemic inammatory response associated trans-capillary leakage of plasma proteins is possible to prevent by increase serum albumin levels. To conclude albumin as priming solution revealed better than crystalloid +FFPin cardiopulmonary bypass surgery in paediatric age group.