Effect of Aloe vera Juice on the Toxicity Induced by Ethionamide and Para Amino Salicylic Acid on Histological Alterations in Sprague-Dawley Rats

Fresh Aloe vera plant leaves were brought from botanical garden and sample was identified and brought to the laboratory in the Department of Zoology, Patkar-Varde College, Goregaon (W), Mumbai.50 grams of leaves were then grounded with 50ml of distilled water in sterilized pestle and mortar.The yield was being calculated based on weight of the extract compared to the weight of the pulp of the leaves.Forty eight (48) Sprague-dawley rats (average weight 150 -250 g) of either sex were used for the experiment.The drugs ETH and PAS drug and Aloe vera juice were given to respective groups daily for 28 days.At the end of study animals were dissected and various tissues/ glands were processed for their histological studies.From the histology study, it was found that the anti-tuberculosis drugs ETH and PAS induced toxicity in male and female Sprague-dawley rats by disturbing the histological structure from minimal to mild changes in the histoarchetecture of lungs, Heart and Kidneys of male and female Sprague-dawley rats either independently or in combination.It was also found that when the anti-tuberculosis drugs ETH and PAS co-administered with Aloe vera juice found amelioration of the histoarchetecture of lungs, Heart and Kidneys of male and female Sprague-dawley to normal.It was also found that, the rats treated with ETH and PAS drugs independently or in combination with Aloe vera juice, no histoarchetectural changes were observed in Brain, Pancreas, Spleen, testes, and ovaries of rat.Thus, it confirms the antioxidant, anti-inflammatory and free scavenging property of Aloe vera juice to protect the histological structures of the different organs and glands of Sprague-dawley rat.