Venlafaxine is approved in adults to treat depression, anxiety or panic disorders, while its use in children and adolescents is off-label. Our study aimed to examine the relationship between dose and serum levels of venlafaxine and its active metabolite O-desmethylvenlafaxine (active moiety, AM) to explore a potential age- and indication- specific therapeutic reference range (TRR) in pediatric patients.
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Ortmann et al. (2024) studied this question.
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