Elevation of alpha-1 acid glycoprotein during acute infection increases clozapine levels without signs of intoxication

The monitoring of plasma levels of clozapine – one of the most effective antipsychotics – is highly recommended. Acute inflammatory processes can increase clozapine levels. Alpha-1 acid glycoprotein (AGP), an acute phase protein that significantly increases during inflammation, could also play a role in explaining the link between inflammation and clozapine concentration. This is the first case report that directly compares clozapine levels with AGP levels during an acute infection in a patient under continuous clozapine treatment.