Plasma concentrations of clozapine (CLZ) vary due to several factors, including age, sex, smoking habits, caffeine consumption, and comedication. Genetic variations might also explain the variations for plasma CLZ (2). Among genetic polymorphisms that may have a role in CLZ metabolism, CYP1A2*1F is a strong candidate.. Cytochrome P450 oxidoreductase (POR) gene POR*28 variation is also potentially a considerable target.
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Demirbugen et al. (2024) studied this question.
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