Introduction: Hirschsprung's disease (HSCR) is characterized by absence of ganglion cells in the submucosal and myenteric plexus of colon. Surgery—standard treatment but has significant morbidity. Per rectal endoscopic myotomy (PREM) is a novel third space procedure described for treatment of HSCR.
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Pagadapelli et al. (2024) studied this question.
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