A Case Series of Esophageal Pemphigus Vulgaris—A Rare Cause of Dysphagia and Odynophagia

Background and Aim: Pemphigus vulgaris (PV) is characterized by intraepithelial blister formation, due to acantholysis by immunoglobulin-G antibodies against the keratinocyte cell surface of mucous membranes and skin. It may present with dysphagia, odynophagia, and rarely hematemesis, though majority are asymptomatic. Very few cases have been reported with esophageal involvement in PV. Esophageal involvement of PV is usually overlooked, as routine endoscopy is not performed for cutaneous manifestations. This study emphasizes on early identification through endoscopic evaluation and histological confirmation which is crucial for appropriate management.