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February 29, 2024Laboratory Medicine

A clinical update of compound heterozygosity for hemoglobin Hekinan II [a27(B8)Glu–Asp; HBA1: c.84G>T] variant in China

Liqiu Pan Yuling Qiu Lihua Ye Linlin Li Yuanyuan Huang Wuning Mo Faquan Lin

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Abstract

Hemoglobin (Hb) Hekinan II (A27; Glu-Asp) is an α-chain variant, and its interaction with the common Southeast Asian (--SEA/) α-thalassemia (α-thal) deletion is rarely reported. This study provides a clinical update of Hb Hekinan II associated with (--SEA/) α-thal.

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Cite This Study

Pan et al. (2024) studied this question.

synapsesocial.com/papers/68e76d10b6db6435876e32c8 https://doi.org/10.1093/labmed/lmae023

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Interactions of electrophoretically silent hemoglobin Hekinan II [HBA1:c.84G>T] with various forms of α-thalassemias and other hemoglobinopathies: novel insights into the molecular and hematological characteristics and genetic origins2024 · 2 citations
2Hb H disease associated with compound heterozygosity for -- <sup>SEA</sup> deletion and a novel alpha globin chain variant ( <i>HBA2</i> :c.175C>A) on the distal histidine in a Chinese family2024 · 1 citations
3Hemoglobin Hekinan II ( <i>HBA1</i> :c.84G&gt;T): an electrophoretically silent α-globin variant missed by routine screening in northern ThailandOriginal Research · 2026
4Hb A <sub>2</sub> -Guangxi [δ79 (EF3) Asp→Asn, <i>HBD</i> : C.238G > A] and polyA + 70 ( <i>HBD</i> : C.*200G > A): Two Novel δ-Globin Gene Mutations Identified in a Chinese Family2024
5First Case of Compound Heterozygotes for Hb G-Georgia (HBA2:c.287C>T)/α0-thalassemia --SEA Deletion Found in Northern Thailand2025