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Animal study reveals senescent and inflammatory podocyte phenotypes in hypertensive and obese mice, suggesting accelerated cellular aging drives glomerular dysfunction.
Hypertension and obesity can lead to glomerular dysfunction in patients, causing podocyte injury and depletion. Here, young mice given deoxycorticosterone acetate or a high-fat diet to induce hypertension or obesity, respectively. mRNA sequencing of isolated podocytes showed transcriptional changes consistent with senescence, a senescent-associated secretory phenotype, and aging, which was confirmed by immunostaining. Ongoing studies are determining the mechanistic roles of the accelerated aging podocyte phenotype in experimental hypertension and obesity.
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McKinzie et al. (2024) studied this question.
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