An experimental and theoretical investigation of the nickel-catalyzed arylative ring-opening/lactonization cascade reactions of oxabicyclic alkenes with aryl halides is reported. The reaction functionalized bicyclo[3.2.1]lactone products in good yields with complete regio- and stereoselectivity. The mechanism and origins of selectivity in the nickel-catalyzed cascade reaction were examined at the ωB97X-D/Def2-TZVPP level of theory.
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Pounder et al. (2024) studied this question.
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