Association of Serum Netrin-1 Level with Metabolic Syndrome Components in Gorgan

Introduction: Metabolic syndrome (MetS) is a complex and multi-factorial condition that affects millions of people worldwide. Netrin-1 may have an important function in metabolic processes. Aim: There are controversial studies about the role of netrin-1 in MetS. Therefore, the aim of this study was to assess the serum level of netrin-1 and its association with MetS components in our study subjects in this area. Materials and Methods: The National Cholesterol Education Program, Adult Treatment Panel III (NCEP, ATP III) criteria were used to include individuals with MetS. Results: Waist circumference, Systolic blood pressure, diastolic blood pressure, fasting blood glucose (FBG), Triglyceride (TG), High-density lipoprotein cholesterol (HDL-C), and netrin-1 were significantly higher in subjects with MetS than those without MetS (Except HDL-C). FBG and TG were significantly higher in type 2 diabetic patients with MetS than those without MetS (Except HDL-C). Netrin-1 showed a significant positive correlation with FBG in type 2 diabetic patients without MetS. Conclusion: This study may provide that future research should focus on investigating the potential therapeutic role of netrin-1 in the management and prevention of T2DM, and its potential impact on the diagnosis and management of this condition should not be overlooked.