Fed‐batch performance profiles for mAb production using different intensified N − 1 seed strategies are CHO cell‐line dependent

Yawen Tang; Jianlin Xu; Mengmeng Xu; Zhuangrong Huang; Johanna Santos; Qin He; Michael Borys; Anurag Khetan

doi:10.1002/btpr.3446

February 28, 2024Biotechnology Progress

Fed‐batch performance profiles for mAb production using different intensified N − 1 seed strategies are CHO cell‐line dependent

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Key Points

Fed-batch mAb production performance varies significantly across distinct CHO cell line models when implementing intensified N - 1 seed strategies for bioreactor culture.
Higher inoculation cell densities of 2-20 × 10 were targeted during the final seed scale-up step to inoculate the production bioreactor across cell culture processes.
Optimized seed train protocols may enhance fed batch yields, though cell line dependence highlights the need for tailored strategies in preclinical CHO cell line models.

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Implication

Preclinical evaluation demonstrates variable fed-batch monoclonal antibody production across CHO cell lines, indicating seed strategies require tailored optimization.

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Cite This Study

Tang et al. (2024) studied this question.

synapsesocial.com/papers/68e77215b6db6435876e76fb https://doi.org/10.1002/btpr.3446

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Fed‐batch performance profiles for mAb production using different intensified N − 1 seed strategies are CHO cell‐line dependent

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Fed‐batch performance profiles for mAb production using different intensified N − 1 seed strategies are CHO cell‐line dependent

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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