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February 28, 2024Meditsinskiy sovet = Medical CouncilOpen Access

Appendix: “an appendage to a twelve-meter gut or a storehouse for microbiota”?

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Authors

ИЗИ. Н. ЗахароваИОИ. М. ОсмановSKS. A. Korovin

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Overview

Review highlights the immunomodulatory and microbiome reservoir functions of the vermiform appendix in pediatric care, suggesting removal may affect ulcerative colitis risk.

Key Points

  • Laparoscopic appendectomy complication rates in children have dropped to 5–7%, while the vermiform appendix is recognized as a reservoir for commensal gut microbiota.
  • Post-operative complications occur in 5–7% of pediatric cases, yet questions remain regarding incidental removal during mild macroscopic inflammation.
  • Review highlights how mucosa-associated lymphoid tissue in the appendix regulates gut immunity, suggesting that surgical removal may elevate ulcerative colitis risk.

Cite This Study

Захарова et al. (2024) studied this question.

synapsesocial.com/papers/68e77330b6db6435876e7e62https://doi.org/10.21518/ms2024-004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the Immunological Role of the Microbial Composition of the Appendix and the Associated Risks of Appendectomies2025 · 9 citations
  2. 2The Appendix2026
  3. 3Modern Pathogenesis, Diagnosis and Management - Acute Appendicitis2024
  4. 4Is Appendicectomy Outdated in the Management of Paediatric Appendicitis?2026
  5. 5Childhood appendectomy is linked with higher digestive, respiratory and genitourinary disease risk but lower IBD risk2026