Transcriptomic analysis reveals cell-type-specific metabolic reprogramming in clear cell renal cell carcinoma, highlighting widespread heterogeneity across the tumor microenvironment.
Clear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to encompass diverse cell types within the tumor microenvironment. Nonetheless, current research on metabolic reprogramming in renal cell carcinoma mostly focuses on either tumor cells alone or conducts analyses of all cells within the tumor microenvironment as a mixture, thereby failing to precisely identify metabolic changes in different cell types within the tumor microenvironment.
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Yang et al. (2024) studied this question.
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