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February 26, 2024JAIDS Journal of Acquired Immune Deficiency SyndromesOpen Access

Impact of Chronic HIV Infection on Acute Immune Responses to SARS-CoV-2

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Authors

SOSkye OpsteenUniversity of Alabama at BirminghamTFTim FramUniversity of Alabama at BirminghamJFJacob K. FilesUniversity of Alabama at Birmingham

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Implication

Observational cohort finds elevated immune activation and exhaustion in people with HIV during acute COVID-19, suggesting chronic dysregulation alters acute disease.

Key Points

  • Chronic HIV infection increases immune activation and exhaustion marker expression during acute COVID-19 infection.
  • Across the cohort (n = 20 PWH, n = 41 PWOH), hospitalized PWH showed lower nonclassical monocyte levels and elevated CD8+ T cell markers.
  • Flow cytometric analyses of peripheral blood mononuclear cells sampled within 21 days of symptom onset tracked immune responses.
  • Findings demonstrate how chronic HIV alters acute antiviral immunity, raising questions about risks for postacute sequelae.

Cite This Study

Opsteen et al. (2024) studied this question.

synapsesocial.com/papers/68e778dab6db6435876ed82chttps://doi.org/10.1097/qai.0000000000003399
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