February 24, 2024Scientific ReportsOpen Access

High-voltage pulsed radiofrequency improves ultrastructure of DRG and enhances spinal microglial autophagy to ameliorate neuropathic pain induced by SNI

View Full Paper

Ask AI

Bookmark

Authors

RCRi ChenFujian Medical University XXXueru XuZhejiang University YYYoufen YuFujian Medical University

Discussion

Member takes

Implication

Animal study reveals that high-voltage pulsed radiofrequency alleviates neuropathic pain in nerve-injured rats, indicating relief via restored ganglionic structure and microglial autophagy.

Key Points

Pulsed radiofrequency alleviates spared nerve injury-induced neuropathic pain in rats, with 85 V stimulation achieving optimal therapeutic relief.
Radiofrequency electrode placement at the L5 dorsal root ganglion reduces activating transcription factor 3 while suppressing local neuroinflammation.
Highlights dorsal root ganglion repair and microglial autophagy as therapeutic targets, though validation remains restricted to a rodent nerve injury model.

Cite This Study

Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e77b43b6db6435876f0071 https://doi.org/10.1038/s41598-024-55095-5

View Full Paper

Ask AI

Bookmark

Implication

Animal study reveals that high-voltage pulsed radiofrequency alleviates neuropathic pain in nerve-injured rats, indicating relief via restored ganglionic structure and microglial autophagy.

High-voltage pulsed radiofrequency improves ultrastructure of DRG and enhances spinal microglial autophagy to ameliorate neuropathic pain induced by SNI

Discussion

Member takes

Implication

Key Points

Cite This Study

High-voltage pulsed radiofrequency improves ultrastructure of DRG and enhances spinal microglial autophagy to ameliorate neuropathic pain induced by SNI

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider