February 23, 2024Nature CommunicationsOpen Access

Complex regulatory networks influence pluripotent cell state transitions in human iPSCs

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Authors

TATimothy D. ArthurUniversity of California, San Diego JNJennifer NguyenLos Angeles County Department of Public Health ADAgnieszka D’Antonio‐ChronowskaUniversity of California, San Diego

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Epigenetic and genetic analysis reveals heterogeneous pluripotent state proportions across human iPSC lines, suggesting that complex regulatory networks drive cell state transitions.

Key Points

Pluripotent cell state proportions vary widely across hiPSC lines, driven by the coordinated co-accessibility of elements within discrete regulatory networks.
Across hundreds of lines, 13 gene network modules correlated with regulatory modules, while the NANOG-OCT4 complex was enriched for large-effect regulatory variants.
Epigenetic and genetic analyses highlight extensive regulatory complexity in self-renewal, suggesting inherited genetic factors actively guide pluripotent cell transitions.

Cite This Study

Arthur et al. (2024) studied this question.

synapsesocial.com/papers/68e77c94b6db6435876f0e34 https://doi.org/10.1038/s41467-024-45506-6

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Implication

Epigenetic and genetic analysis reveals heterogeneous pluripotent state proportions across human iPSC lines, suggesting that complex regulatory networks drive cell state transitions.

Complex regulatory networks influence pluripotent cell state transitions in human iPSCs

Discussion

Member takes

Implication

Key Points

Cite This Study

Complex regulatory networks influence pluripotent cell state transitions in human iPSCs

Discussion

Member takes

Implication

Key Points

Cite This Study

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