February 23, 2024Annals of Surgery

Distinguishing Clinical From Statistical Significances in Contemporary Comparative Effectiveness Research

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Most authors do not define clinically significant differences in outcomes, with 8.5% reporting this clearly.
In 2.3% of studies, changes in clinical decision-making were based solely on statistical significance.
Observational analysis across 307 recent studies highlights that clinical standards defined significance in 25 studies out of 26 reported cases/efforts to improve healthcare outcomes and cost efficiency aren't always aligned with actual clinical impact.

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Implication

Randomized trial reveals low prevalence of clinical significance reporting in contemporary comparative effectiveness research, suggesting misinterpretation of results.

Cite This Study

Gikandi et al. (2024) studied this question.

synapsesocial.com/papers/68e77c94b6db6435876f0f01 https://doi.org/10.1097/sla.0000000000006250

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Implication

Randomized trial reveals low prevalence of clinical significance reporting in contemporary comparative effectiveness research, suggesting misinterpretation of results.

Distinguishing Clinical From Statistical Significances in Contemporary Comparative Effectiveness Research

Key Points

Discussion

Implication

Cite This Study

Distinguishing Clinical From Statistical Significances in Contemporary Comparative Effectiveness Research

Key Points

Discussion

Implication

Cite This Study

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Also Consider