Nitrene-transfer from azides to isocyanides: Unveiling its versatility as a promising building block for the synthesis of bioactive heterocycles

Cross-coupling azide and isocyanide have recently gained recognition as ideal methods for efficiently synthesizing asymmetric carbodiimides. This reaction exhibits high reaction rates, efficiency, and favorable atom/step/redox economy. It enables the nitrene-transfer process, facilitating the formation of C-N bonds and providing a direct and cost-effective synthetic strategy for generating diverse carbodiimides. These carbodiimides are highly reactive compounds that can undergo