Efficacy of a moisturizing cream and facial mask for alleviating skin problems associated with medical mask use: A half‐face, randomized controlled study

Background Prolonged use of medical masks has increased skin‐related issues. Aim To evaluate the efficacy of a facial cream and facial mask in mitigating medical mask related skin symptoms. Methods Healthy women were randomly assigned to apply a facial cream ( n = 32) or a facial mask plus a facial cream ( n = 32) on half‐faces after wearing medical masks for 4 h (T b ). Transepidermal water loss (TEWL), dryness score, and redness area were assessed at T b and 10 min after using the cream (T 1 ) in the facial cream group, and at T b , 1 h after using the facial mask (T 2 ), and 10 min after using the cream (T 3 ) in the combined use group. Results In the facial cream group, the treated half‐face showed significantly better improvements from T b to T 1 in TEWL (−2.95 ± 0.38 vs. −0.68 ± 0.35 g/h·cm 2 , p < 0.001) and skin dryness score (−1.00 ± 0.12 vs. 0.00 ± 0.00, p < 0.001). In the combined use group, the treated half‐face showed significantly better improvements from T b to T 2 and T 3 in TEWL (T 2 , −3.46 ± 0.33 vs. −0.09 ± 0.13 g/h·cm 2 ; T 3 , −4.67 ± 0.31 vs. −0.28 ± 0.22 g/h·cm 2 ) and skin dryness score (T 2 , −0.63 ± 0.13 vs. 0.03 ± 0.03; T 3 , −0.94 ± 0.17 vs. 0.19 ± 0.07) (all p < 0.001) then the untreated half‐face. The combined use group had significantly lower TEWL at T 3 than T 2 ( p < 0.05). The reduction in redness area was similar between the treated and untreated half‐faces in both groups. Conclusions The test facial cream and mask significantly improved skin barrier function and alleviated dryness symptoms associated with medical mask use, with the combined use offering superior benefits.