Experimental animal study demonstrates that vitamin C reduces amoxicillin-clavulanic acid liver toxicity in male albino rats, suggesting a protective therapeutic role against hepatic injury.
Background: Amoxicillin/clavulanic acid (AC) is used to treat a variety of bacterial infections, most frequently linked to drug-induced hepatotoxicity. Vitamin C is a necessary, water-soluble micronutrient serves as an antioxidant and cofactor for several enzymes, Aim of the work: Our research aimed to study the potential Ameliorative role of vitamin C against the amoxicillin- clavulanic acid induced hepatotoxic effects on the liver of the adult male albino rats.Materials and methods: 30 adult albino rats were used. The animals were equally divided into three groups, each of them consisting of 10 rats. Group I: "control" Animals were not subjected to any interference. Group II: were given Amoxicillin-Clavulanic Acid induced Hepatotoxicity. Group III: were given Amoxicillin-Clavulanic Acid induced Hepatotoxicity and Vitamin C treated it.At the end of the experiment, blood samples and livers were collected for biochemical and histological evaluation.Results: Administration (AC) had apparent hepatotoxic effects in the form of elevations in blood liver enzymes, disruption of the antioxidant capacity of liver tissue. Co-administration of Vitamin C could reduce all the biochemical and histological effects of AC.Conclusion: Vitamin C a has protective and therapeutic effects on AC-induced liver damage in rats.
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Mohammed et al. (2024) studied this question.
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