"Stiff Person Syndrome: Taxonomic Analysis Supports Use of Large Data Methods to Appraise Major Comorbidities of a Rare Disorder"

Stiff-person syndrome (SPS), a rare neuro-immunological condition producing profound and insidious stiffness, often manifests with marked elevation of autoantibodies to glutamic acid decarboxylase-65 (GAD65 Abs). Patient sparsity has impeded understanding of SPS. We sought to characterize SPS features in a representative sample of U.S. older adults, using unbiased large data methods, with validation.