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October 9, 2025Circulation Research

Abstract Wed078: Post-transcriptional Regulation of Adrenal-Heart Crosstalk in Heart Failure with Preserved Ejection Fraction

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Authors

FAFrancisca AkhigbeKLKarl Michael LUXTLTian Liu

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Overview

Research demonstrates the role of EPRS in regulating catecholamine synthesis and cardiac function in HFpEF, suggesting new therapeutic targets.

Key Points

  • EPRS inactivation in adrenal glands protects against obesity and diabetes in HFpEF models, improving metabolic outcomes.
  • Significant induction of EPRS and catecholamine synthesizing enzymes occurs in adrenal glands after L-NAME/HFD challenge.
  • EPRS-aKO mice show improved left ventricular diastolic function and decreased pathological markers, indicating reduced cardiac dysfunction.
  • Targeting adrenal-heart crosstalk mediated by EPRS may offer new strategies for treating heart failure with preserved ejection fraction.

Cite This Study

Akhigbe et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb1ehttps://doi.org/10.1161/res.137.suppl_1.wed078
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Wed091: Biomechanical and Transcriptomic Remodeling of the Heart in Heart Failure with Preserved Ejection Fraction2025
  2. 2Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction2024 · 16 citations
  3. 3Impairment of the adrenergic reserve associated with exercise intolerance in a murine model of heart failure with preserved ejection fraction2024 · 9 citations
  4. 4EPRS Regulates Proline-rich Pro-fibrotic Protein Synthesis during Cardiac Fibrosis2019 · 6 citations
  5. 5Cardioprotective Effects of Angiotensin 1‐7 in Heart Failure with Preserved Ejection Fraction (HFpEF)2021 · 2 citations