October 9, 2025Circulation Research

Abstract Wed088: Distinct Multi-Omic Signatures Differentiate Type I Diabetes-Associated HFpEF from Obesity-Related HFpEF

Q: What is the clinical evidence from this study?

Study design: Other. Population: Heart failure with preserved ejection fraction (HFpEF). Intervention: Type 1 diabetes-associated HFpEF model vs. Obesity-related HFpEF model. Primary outcome: Mechanistic differences in cardiac remodeling, inflammation, and systemic metabolism.

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Key result

Type 1 diabetes HFpEF drives severe metabolic and immune dysregulation distinct from obesity-related HFpEF.

Authors

LWLin WeiCapital Medical University PHPatrick C. HsiehUniversity of Southern California

Discussion

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Implication

This study reveals distinct mechanisms of HFpEF in type 1 diabetes and obesity, highlighting therapeutic targets for intervention.

Key Points

Distinct cardiac remodeling mechanisms are observed in HFpEF patients with type 1 diabetes compared to obesity.
Single-cell profiling indicated unique chromatin changes and gene expression patterns in diabetic versus obesity-related HFpEF.
Metabolomic and gut microbiome analyses uncover unique metabolic disruptions linked to both HFpEF models.
This research emphasizes different inflammatory and metabolic pathways contributing to HFpEF progression in type 1 diabetes.

PICO

Population

Heart failure with preserved ejection fraction (HFpEF)

Exposure / Comparator

Type 1 diabetes-associated HFpEF model vs Obesity-related HFpEF model

Primary Outcome

Mechanistic differences in cardiac remodeling, inflammation, and systemic metabolism

Cite This Study

Wei et al. (2025) studied Heart failure with preserved ejection fraction (HFpEF). Type 1 diabetes-associated HFpEF model vs. Obesity-related HFpEF model was evaluated on Mechanistic differences in cardiac remodeling, inflammation, and systemic metabolism. A murine model of Type 1 diabetes-associated HFpEF demonstrated severe metabolic disorders and immune dysregulation, distinct from the cardiomyocyte remodeling seen in obesity-related HFpEF.

synapsesocial.com/papers/68e77f09d1c187e1c108fbba https://doi.org/10.1161/res.137.suppl_1.wed088

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Abstract Wed088: Distinct Multi-Omic Signatures Differentiate Type I Diabetes-Associated HFpEF from Obesity-Related HFpEF

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Abstract Wed088: Distinct Multi-Omic Signatures Differentiate Type I Diabetes-Associated HFpEF from Obesity-Related HFpEF

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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Also Consider