Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: Etiology and sex-dependent differences
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Discussion
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Implication
Analyses reveal diastolic dysfunction and distinct gene expression in HFpEF models, indicating etiology and sex differences.
Key Points
- The aim was to compare mechanisms of excitation-contraction coupling, electrophysiology, and gene transcription in HFpEF models with a focus on sex differences.
- Utilized two HFpEF murine models: HFD+L-NAME and db/db+Aldo.
- Conducted morphometry, echocardiography, cellular electrophysiology, and RNA-sequencing.
- Analysed diastolic dysfunction and action potential changes across sexes in both models.
- Diastolic dysfunction was more severe in db/db+Aldo mice, especially in females.
- Marked proarrhythmic action potential changes were observed in db/db+Aldo mice of both sexes.
- Distinctive gene expression profiles were identified between the two HFpEF models.
Cite This Study
Hegyi et al. (2025) studied this question.