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This is a Literature Review study.

October 9, 2025International Journal of Molecular SciencesOpen Access

Targeting Transferrin Receptor 1 for Enhancing Drug Delivery Through the Blood–Brain Barrier for Alzheimer’s Disease

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Authors

XSXiaoxia ShenUniversity of Nottingham HLHuan LiHarvard University BZBeiyu ZhangShanghai Chengtou (China)

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Implication

This review examines drug delivery strategies targeting transferrin receptor 1 to improve outcomes in Alzheimer's disease, emphasizing the role of the blood-brain barrier.

Key Points

Transferrin receptor 1-targeting strategies may improve drug delivery across the blood-brain barrier for alzheimer's disease.
The review highlights various delivery methods, including nanoparticles and ligand conjugates, showing potential for therapeutic applications.
Tar1 receptor stability in alzheimer’s mouse models suggests promise for consistently overcoming delivery challenges.
Despite the promise of TfR1-targeted strategies, challenges like receptor saturation and competition with endogenous transferrin remain critical.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fbbc https://doi.org/10.3390/ijms26199793

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Implication

This review examines drug delivery strategies targeting transferrin receptor 1 to improve outcomes in Alzheimer's disease, emphasizing the role of the blood-brain barrier.

Targeting Transferrin Receptor 1 for Enhancing Drug Delivery Through the Blood–Brain Barrier for Alzheimer’s Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Targeting Transferrin Receptor 1 for Enhancing Drug Delivery Through the Blood–Brain Barrier for Alzheimer’s Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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