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October 9, 2025Medicni perspektiviOpen Access

Current understanding of the pathogenetic relationships between chronic obstructive pulmonary disease and type 2 diabetes mellitus: an integrative review

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Integrative review reveals inflammation and oxidative stress increase COPD risk in type 2 diabetes patients.

Patients with type 2 diabetes mellitus have an increased risk of developing chronic obstructive pulmonary disease, linked to systemic inflammation.
Chronic hyperglycemia contributes to worsened lung function and airway remodeling by triggering oxidative stress in patients with COPD.
Adipose tissue plays a crucial role in chronic inflammation by producing pro-inflammatory adipokines, which affects COPD progression.
The interconnectedness of chronic obstructive pulmonary disease and type 2 diabetes necessitates further research for improved diagnostic and treatment approaches.

Sanina et al. (2025) studied this question.

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