FIGURE 6 from Stromal Signals Dominate Gene Expression Signature Scores That Aim to Describe Cancer Cell–intrinsic Stemness or Mesenchymality Characteristics

Influence and association of signature gene expression profiles on signature scores in colorectal cancer (CRC) bulk RNA-seq samples. Each dot in a panel represents a signature gene of the respective signature. A gene at the bottom weakly influences the overall signature score. A gene at the top strongly influences the overall signature score. Genes on the left are stronger correlated with low cancer cell content. Blue coloring of data points indicates a higher expression in fibroblasts than in malignant cells in our scRNA-seq analyses. Labeled genes are the top three genes with the highest expression in fibroblasts.