Therapeutic role of curcumin on Beta Amyloid Protein, Biochemical and Oxidative changes in rats with streptozotocin induced diabetes

Diabetes is one of the most common endocrine metabolic diseases. It was aimed to investigate the therapeutic role of curcumin on Beta Amyloid Protein (TBAP), Biochemical and Oxidative changes in rats with streptozotocin-induced diabetes.The study consisted of five groups (n = 8 rats per group): control, diabetic, curcumin, curcumin in diabetes induction, and curcumin after diabetes induction.In order to induce diabetes, a single dose of 45 mg/kg Streptozotocin was administered to the 2nd and 4th groups on the 1st day of the experiment and to the 5th group on the 28th day. Curcumin was administered to groups 3, 4 and 5 via oral gavage at a dose of 100 mg/kg/day for 35 days. It was observed that blood sugar levels were close to each other in group 1 and group 3, but were high in the diabetic groups (P < 0.05). Streptozotocin and curcumin application to diabetic rats reduced the level of beta amyloid protein in the brain. It was determined that the effect of curcumin application on hyperglycemia, insulin resistance and kidney function activity tests was not significant. It was determined that curcumin had an effect on reducing oxidative stress caused by diabetes and increasing antioxidant activity.