Immediate Hypersensitivity to Chlorhexidine: Experience From an Allergy Center in China

( Anesthesiology. 2023; 138:364–371) Chlorhexidine is a commonly used topical antibacterial agent for Gram-positive and Gram-negative bacteria and can be found in a great variety of antibacterial products. As use has increased, instances of allergic reactions to the compound have been reported, including contact dermatitis and anaphylaxis. As chlorhexidine is a component ingredient in many products used perioperatively, allergic reactions occurring in this setting can often be attributed to other factors rather than chlorhexidine as the true source. This study was designed to summarize the experience of an allergy center in China with chlorhexidine reactions.