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February 21, 2024European Journal of Clinical InvestigationOpen Access

Loss of CEACAM1 in hepatocytes causes hepatic fibrosis

Sobia Zaidi Suman Asalla Harrison T. Muturi Lucia Russo Raziyeh Abdolahipour Getachew D. Belew Maria Benitez Iglesias Mary Feraudo Lensay Leon Enoch Kuo Xiuli Liu Sivarajan Kumarasamy Hilda E. Ghadieh Cara Gatto‐Weis Ali Zarrinpar Sergio Duarte Sonia M. Najjar

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Abstract

The role of insulin resistance in hepatic fibrosis in Metabolic dysfunction-Associated SteatoHepatitis (MASH) remains unclear. Carcinoembryonic Antigen-related Cell Adhesion Molecule1 protein (CEACAM1) promotes insulin clearance to maintain insulin sensitivity and repress de novo lipogenesis, as bolstered by the development of insulin resistance and steatohepatitis in AlbuminCre + Cc1

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Zaidi et al. (2024) studied this question.

synapsesocial.com/papers/68e7832ab6db6435876f6016 https://doi.org/10.1111/eci.14177

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Cell-specific regulation of insulin action and hepatic fibrosis by CEACAM12024 · 7 citations
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